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The combined effect of different levels of dietary n-3 HUFAs [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)] with α-Tocopherol on growth parameters (final weight, SGR, FCR, and some health indices (hematocrit, plasma lipid and lipoprotein levels) of the Caspian trout fry, Salmotruttacaspius, was investigated. Six experimental diets containing three different dietary levels of n-3 HUFAs (Low: 1 + 0.5, DHA+ EPA, Medium: 2 + 1, DHA + EPA, High: 4 + 2, DHA + EPA g/100g diet) with two different levels of α-Tocopherol (Low: 300 and High: 1000 mg/kg diet) were prepared and named: LL, LH, ML, MH, HL, HH (HUFA/α-Tocopherol) groups, respectively. Fries (600 ± 25 mg) were randomly distributed in tanks (50 fries per tank) and were fed with the experimental diets for 10 weeks. The work was conducted in triplicates. Results showed that the SGR and body weight were significantly higher in the MH group than other groups. Hematological parameters, especially plasma lipids and lipoproteins were more influenced by the dietary n-3 HUFA and vitamin E and interaction between vitamin E and n-3 HUFA has minimal effect on these parameters. Results of this study suggested that increasing of dietary n-3 HUFA could improved growth performance and enhance health in the Caspian trout fry when appropriate level of α- Tocopherol supplemented.