Understanding the environment and geopolitical analysis of neighboring border cities are the most important factors that should be taken into account to establish security and expand bilateral relations, which are sought after by countries, especially cities in Southwest Asia. In recent years, some actions of neighboring countries or trans-regional countries have led to insecurity in urban areas. By understanding this concept, the characteristics of the eastern borders of Iran and the relations between Iran and Pakistan, including the cities of Zahedan and Quetta, will be studied in detail by employing a descriptive-analytical research method.