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Mnemiopsis leidyi population activities first were recorded during the coastal observations in 2001 in which its population considerably increased afterward and now sustained the southern Caspian Sea. Maximum summer-autumn M. leidyi abundance was recorded in euphotic layer in 2002 (851±85 ind.m^-3) and maximum biomass was in 2001 with 48.1±14.4 g.m^-3) while minimum were in aphotic layer. In years 2003 to 2011, M. leidyi abundance and biomass sharply declined to 1-843 ind.m^-3 and 0.07-37.7 g.m^-3, respectively. The length-frequency distribution of Mnemiopsis showed larval, juveniles and transitional stages that made up 98.6% of the total population. In the southern Caspian Sea, Acartia tonsa was the highest number of mesozooplankton species (36 species) which decreased tenfold after Mnemiopsis invasion during 2001-2010. Fecundity experiments of Mnemiopsis showed the average of 8 eggs. day^-1, with a maximum of 35 eggs.day^-1which increased with increasing body length. The main food was larger amounts of zooplankton prey such as copepodites and adult of A. tonsa. It seems the sharp decreased of Mnemiopsis abundance could be related the decreasing of ova reproduction; and food ability is the main reasons of M. leidyi sustained in the southern Caspian Sea. The objective of present study was to provide information about parameters influencingthe M. leidyi decreased after initial bloom invasion in the southern Caspian Sea.

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A 27 day study was undertaken to evaluate the effects of aqueous extracts of Hypericumperforatum on hemato-serological parameters and survival of rainbow trout (Oncorhynchusmikiss) under thermal stress (20 ± 2 ◦C). A total of 360 rainbow trout (97.2 ± 1.6g) were divided randomly into four groups and  immersed in different concentrations (0, 250, 500 and 750 ppm) (T0, T25, T50 and T75) of aqueous extracts of H. perforatum. The blood samples were collected on day 12 and 27 and hemato-serological parameters were determined. In stage 1, the total red blood cell, hemoglobin and hematocrit didn’t show a significant difference among controls and treatments but in stage 2, those parameters were significantly increased in T50 and T75 compared to T0 and T25.  The total white blood cell, lymphocytes, total protein, albumin, and total IgM showed a significant increase in treatments compared to control but the results in the neutrophils was opposit. The MCV and MCH didn’t significantly change in two stages but the MCHC of T75 were significantly higher than T0 and T25. The glucose of T50 and T75 were significantly lower than T0 and T25. The hepatic enzymes, ALT and AST of T75 significantly increased compared to other groups in stage2. The highest and lowest survival rates were observed in T50 and T0, respectively. Based on the results, it seems that Hypericumperforatum could control the effectsof stress and increase the survival rate of rainbow trout when exposed to chronic heat stress.

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Iranian mosquitoes (Diptera: Culicidae) include 73 species across eight genera. The fauna of mosquitoes in Guilan Province comprises 34 species classified into seven genera. A faunistic study of mosquitoes was conducted with emphasis on an aggressive biter mosquito reported by local people in Anzali and Rasht Cities of Guilan Province, northern Iran. Collections were made by hand catches using manual aspirators, light traps, BG lure traps and ovitraps during August–November 2023 in all 17 counties of the province. Species identification was carried out using morphological keys and molecular analysis of the barcode region of the cytochrome c oxidase subunit I (COI) gene. In total, 29 larvae and 896 adult specimens were collected which were not recognized as a species previously known to occur in the province. The aggressive biter mosquito was morphologically identified as Aedes albopictus (Skuse, 1895). The sequences of the barcode region of the COI gene of the species were generated for the first time in the country. This species was collected in 14 counties of the province. Thus, the mosquito fauna of Guilan Province increased to 35 species.

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Since the emergence of the novel SARS-CoV-2 coronavirus in December 2019, various drugs have been proposed as antiviral agents for treating the coronavirus disease-2019 (COVID-19) patients. Among the very first drugs to be utilized in the clinic were the aminoquinolines chloroquine and hydroxychloroquine (HCQ). At the time this work started, the US FDA and EU EMA had given emergency approval for the use of chloroquine and HCQ in COVID-19 patients. Chloroquine and HCQ have been commonly used for treating malaria and various autoimmune diseases. Additionally, both drugs have been shown to exert other therapeutic effects, including antiviral effects against SARS and MERS causing viruses.  The exact antiviral mode of action of Chloroquine and HCQ is unclear even though these drugs exert a broad range of antiviral effects. HCQ is classically considered as an inhibitor of endocytic pathways through  elevation of endosomal pH, its detailed molecular mechanisms of action as an antiviral compound remains elusive In-vitro studies show that both drugs can block the viral replication of SARS-CoV- 2 in cell cultures, but a high-level assessment suggested that calculated extracellular lung concentrations are well below the in vitro efficacy values and therefore the drug has low potential for in vivo activity at standard dosing regimens.