Volume 9, Issue 3 (2020)                   JFST 2020, 9(3): 201-211 | Back to browse issues page

‎ 20.1001.1.23225513.1399.9.3.6.3

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Khajavi M, Hajimoradloo A, Zandi M, Pezeshki-Modaress M, Zamani A, Bonakdar S. Preparation and characterization of drug delivery system based on biodegradable polymer polycaprolactone (PCL) and hydrogel from beluga (Husohuso) cartilage. JFST 2020; 9 (3) :201-211
URL: http://jfst.modares.ac.ir/article-6-47716-en.html
Preparation and characterization of drug delivery system based on biodegradable polymer polycaprolactone (PCL) and hydrogel from beluga (Husohuso) cartilage
Maryam Khajavi1 , Abdolmajid Hajimoradloo * 1, Mojgan Zandi2 , Mohamad Pezeshki-Modaress3 , Abbas Zamani4 , Shahin Bonakdar5
1- Department of Fisheries, Faculty of Fisheries and Environmental Science, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
2- Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, Iran.
3- Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Department of Fisheries, Faculty of Natural Resources and Environment, Malayer University, Malayer, Iran.
5- National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
Abstract:   (2285 Views)
Controlled delivery technology of protein/peptide drugs from biodegradable particles has emerged as one of the eminent areas to overcome problems related to macromolecules formulation. The goal of the present study was to develop protein-loaded micro-particles using biodegradable polymer, polycaprolactone (PCL) and hydrogel from beluga cartilage. Bovine serum albumin (BSA) was used as a model for protein/ peptide molecules such as GnRH. The double emulsion (W/O/W) technique was selected as one of the most appropriate methods for preparing a drug delivery system for soluble proteins in water. The first emulsion was prepared using ultrasonic and the mechanical agitator was used for achieving the second emulsion. The hydrogel prepared by enzymatic digestion was used in the first aquatic solution. At the present investigation, three groups were considered as the drug delivery system: G1; (PCL/hydrogel/BSA), G2; (PCL/BSA) and G3; (PCL/Alginate/BSA). Findings showed that the morphology of particles was spherical and non-conglomerated in all groups. The comparison of average particle size among groups was also indicated that the particles.
Keywords: Micro-particle, Double emulsion, Hydrogel, PCL, BSA
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Article Type: Original Research | Subject: Fisheries Engineering and Technology
Received: 2020/11/16 | Published: 2020/09/20
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