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The present study was designed to evaluate the effect of acetaminophen on hematologic and blood biochemistry of rainbow trout in a 4-day period. To that end, total 300 fingerlings with an average body weight of 12.5±2.5 g were randomly allocated into 15 polyethylene tanks (with 100L volume). Fingerlings were exposed to five concentrations of acetaminophen, namely, 0, 0.01, 0.1, 1. 10 mg/L for 4 days. Hematologic and Biochemical Parameters of Rainbow Trout (Oncorhynchus mykiss) exposed to Acetaminophen were measured. According to the results, the number of white blood cells was significantly different compared to the control group and other treatments at concentration of 10 mg/l. The number of red blood cells, hemoglobin, mean hemoglobin volume (MCV) and hematocrit were higher in the control group and And the lowest amount was observed at a concentration of 10 mg/l and There was a significant difference between these parameters in different treatments. There wasn´t significant difference in mean corpuscular hemoglobin concentration (MCH) between experimental treatments. There was a significant difference in serum lysozyme enzyme and complement (ACH50) activity in fingerling exposed to acetaminophen. There was a significant difference in cortisol and glucose levels in different treatments so that the most amount of cortisol and glucose showed in the control group and the less amount was observed in treatment 5.

Keywords: Immunity, Acetaminophen, Complement, Lysozyme, Cortisol, Glucose

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